… of cartilage that can lead to severe pain and loss of mobility. … and methylation marks observed
in the articular cartilage. Then … cartilage, of certain CpG sites located in the promoter of the …

… DNA CpG sites were localized in OA-related genes, inducing … degradation of ECM, inducible
nitric oxide synthase (iNOS), … -515-5p/TLR4/MyD88/NF-κB axis [35]. This signaling regulates …

… cartilage degradation which result in chronic pain and loss of … 6 and IL-8), inducible nitric
oxide synthase (iNOS) and tumor … inhibition include the NF-κB and transforming growth factor-…

… Loss of methylation in specific CpG sites … of inducible nitric oxide synthase (iNOS) in OA is
related to the demethylation of an enhancer region, which is one of the binding sites of NF-κB, …

… genes and a decreased methylation of NFκB-sensitive iNOS … RO Loss of methylation in
CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for …

… regulation of methylation levels in their CpG sites. Decreasing … IL-1β-induced TNF-α and
inducible nitric oxide synthase (iNOS) … the expression of receptor activator of the NF-κB ligand (…

… oxide synthase (iNOS) is activated (Figure 1). iNOS, in response, synthesises nitric oxide
(NO)… presents three hypermethylated CpG sites in OA synoviocytes that impair NF-κB binding to …

… -kappa B (NF-κB), inducible nitric oxide synthase (iNOS), and … et al., “Loss of methylation in
cpg sites in the NF-κB enhancer … for gene induction in human articular chondrocytes,” Arthritis …

… modifications, including methylation, acetylation, phosphorylation… might induce chondrocyte
proliferation and cartilage … of NF-κB activity and aggravation of articular cartilage loss and …

… factor (G-CSF), nitric oxide synthase (NOS), neutrophil elastin, … C/EBPβ mRNA expression,
no functional NF-κB-binding site has … C/EBPβ is an intronless gene, and the lack of introns …